Front Pharmacol 1(13):825417 Cheng L, Hu Y, Li YY, Cao X, Bai N, Lu TT, Li GQ, Li N, Wang AN, Mao XM (2019) Glucagon-like peptide-1 receptor agonists and risk of bone fracture in patients with type 2 diabetes: a meta-analysis of randomized controlled trials
Balanced effectiveness and sustainability
This margin of safety provides reassurance, though caution remains appropriate given the limited formal human studies
In general, oral diabetes medicines such as metformin are tried first for blood sugar control before injectables such as Ozempic are considered
As promising as this sounds, we should be careful not to get ahead of the science